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Membraneless organelles are RNA–protein assemblies which have been implicated in post‐transcriptional control. Germ cells form membraneless organelles referred to as germ granules, which contain conserved proteins including Tudor domain‐containing scaffold polypeptides and their partner proteins that interact with Tudor domains. Here, we show that inDrosophila, different germ granule proteins associate with the multi‐domain Tudor protein using different numbers of Tudor domains. Furthermore, these proteins compete for interaction with Tudorin vitroand, surprisingly, partition to distinct and poorly overlapping clusters in germ granulesin vivo. This partition results in minimization of the competition. Our data suggest that Tudor forms structurally different configurations with different partner proteins which dictate different biophysical properties and phase separation parameters within the same granule. 

Jumping spiders (Salticidae) rely on accurate depth perception for predation and navigation. They accomplish depth perception, despite their tiny brains, by using specialized optics. Each principal eye includes a multitiered retina that simultaneously receives multiple images with different amounts of defocus, and from these images, distance is decoded with relatively little computation. We introduce a compact depth sensor that is inspired by the jumping spider. It combines metalens optics, which modifies the phase of incident light at a subwavelength scale, with efficient computations to measure depth from image defocus. Instead of using a multitiered retina to transduce multiple simultaneous images, the sensor uses a metalens to split the light that passes through an aperture and concurrently form 2 differently defocused images at distinct regions of a single planar photosensor. We demonstrate a system that deploys a 3-mm-diameter metalens to measure depth over a 10-cm distance range, using fewer than 700 floating point operations per output pixel. Compared with previous passive depth sensors, our metalens depth sensor is compact, single-shot, and requires a small amount of computation. This integration of nanophotonics and efficient computation brings artificial depth sensing closer to being feasible on millimeter-scale, microwatts platforms such as microrobots and microsensor networks. 

The focal track sensor is a monocular and computationally efficient depth sensor that is based on defocus controlled by a liquid membrane lens. It synchronizes small lens oscillations with a photosensor to produce real-time depth maps by means of differential defocus, and it couples these oscillations with bigger lens deformations that adapt the defocus working range to track objects over large axial distances. To create the focal track sensor, we derive a texture-invariant family of equations that relate image derivatives to scene depth when a lens changes its focal length differentially. Based on these equations, we design a feed-forward sequence of computations that: robustly incorporates image derivatives at multiple scales; produces confidence maps along with depth; and can be trained endto- end to mitigate against noise, aberrations, and other non-idealities. Our prototype with 1-inch optics produces depth and confidence maps at 100 frames per second over an axial range of more than 75cm.